MODAFINIL - INSTRUCTIONS AND USE OF THE DRUG
aboutModafinil is an oral wake-promoting agent. Modafinil has an activating effect similar to sympathomimetic agents, including amphetamine and methylphenidate, although the pharmacological profile of modafinil is not identical to that of sympathomimetic amines.
Effect of modafinil on orexinThe hypothalamus, through the hormones it produces, affects many functions of the body. It is this part of the brain that sends impulses to different organs, thereby activating their work. Figuratively speaking, the hypothalamus is the center that controls all processes occurring in the body, including wakefulness. The orexin-containing neurons of the hypothalamus are responsible for this process. It is orexin that is responsible for vigilance and a sense of wakefulness.
Studies have shown that modafinil activates the neurons that control the release of orexin into the brain . Actually, this ability of modafinil is considered the most important when using the drug for the treatment of narcolepsy, which is known to be associated with a violation of the level of orexi |
Application of ModafinilModafinil is indicated to increase wakefulness in adult patients with excessive sleepiness due to narcolepsy, obstructive sleep apnea, or sleep-wake cycle disorders.
Modafinil - contraindications, side effectsContraindications:Contraindicated in patients with known hypersensitivity to modafinil or its inactive components.
Side effects:In placebo-controlled clinical trials, the most common (≥ 5%) adverse reactions associated with the use of modafinil and more common than placebo patients were: headache, nausea, nervousness, rhinitis, diarrhea, back pain, anxiety , insomnia, dizziness, dyspepsia. |